DigestCheck
DigestCheck is intended for people suffering from digestive disorders and makes it possible to study the parameters involved in intestinal balance.
What is the DigestCheck panel?
The intestine, the “second brain” of the body, plays a major role in the body’s health.
The balance between the intestinal mucosa, microbiota and digestive immune system regulates physiological or pathological variations due to an intestinal infection, inflammation or intestinal hyperpermeability. These are all processes that are known to be involved in many chronic inflammatory or autoimmune diseases, whether they are associated with digestive symptoms or not.
This is why the DigestCheck profile focuses on intestinal balance and is based on four main areas of screening:
- Inflammation of intestinal origin;
- Increased intestinal permeability;
- Imbalance of the intestinal flora;
- Alteration of the immune defences of the intestinal mucous membrane.
What can we expect from DigestCheck?
DigestCheck test allows, on the one hand, the non-invasive evaluation of the digestive sphere function and, on the other hand, the early detection of an intestinal inflammation, an imbalance of the flora (dysbiosis) or an anomaly of the intestinal permeability.
In doing so, we will be able to find clues to explain pathologies such as irritable bowel syndrome, food intolerances, autoimmune diseases or chronic inflammatory diseases.
Who is the DigestCheck profile for?
The DigestCheck profile is intended for everyone, not only those with digestive disorders but also others without digestive symptoms but suffering from disorders that may be the consequence of an imbalance in the digestive ecosystem, such as:
- Unexplained digestive pain, diarrhoea, stubborn constipation;
- Chronic intestinal inflammation (Crohn’s disease, Ulcerative Colitis, Irritable Bowel Syndrome, etc.);
- Disorders related to repeated or long-term use of antibiotics, anti-inflammatory drugs, proton pump inhibitors;
- Overweight, obesity;
- Chronic inflammatory diseases (joint and other);
- Depression, anxiety, trouble concentrating or sleeping; or
- Those wanting a nutritional assessment after digestive surgery, post-radiotherapy, etc.
Parameters
Physical/chemical examination of stools, Blood in stool, Faecal beta-2 definsin, Calprotectin, Faecal secretory IgA, Faecal zonulin, Faecal alpha-1 antitrypsin
More information on DigestCheck
Why does the DigestCheck profile include these parameters specifically?
This panel is based on specific screening tests, carried out on faecal samples:
- General evaluation of the efficiency of the digestive processes (macro and microscopic examination);
- Screening for inflammation of intestinal origin, either high grade (calprotectin) or low grade (beta-2 defensin);
- Screening for increased intestinal permeability (zonulin assay) or exudative enteropathy (alpha-1 antitrypsin);
- Evaluation of local immune stimulation (secretory IgA);
- Stool testing.
This profile could be completed by performing a food intolerances (NutritolTM) test as well as blood assays (IgA anti-transglutaminase, Candida serology, ultra-sensitive CRP…) or a study of the intestinal microbiota.
For further reading…
Fasano A. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci. 2000;113 Pt 24:4435-4440.
Chairatana P, Nolan EM. Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut. Crit Rev Biochem Mol Biol. 2017;52(1):45-56.
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